Methenolone Enanthate, Primobolic Injection, Primobolan Depot, generic name Methenolone Enanthate from Asia Pharma is prescribed to women with breast cancer and AIDS patients.

COMPOSITION 1 amp of Primobolan depot contains metenolone enanthate (17beta-hydroxy-1-methyl-5alpha-androst-1-en-3-one enanthate) 50 mg per 1 ml.

PHARMACOLOGICAL ACTION In aplastic anaemias of various origins - both the idiopathic forms and those with exogenously damaged bone marrow - high doses of metenolone acetate may stimulate bone marrow function, particularly erythropoiesis. Metenolone acetate is a non-17alpha-alkylated.

INDICATIONS Aplastic anaemias.

CONTRA-INDICATIONS Primobolic is contra-indicated in pregnancy as the metenolone acetate contained in the preparation, like all agents, possesses some androgenic activity which may lead to signs of virilisation in the female newborn. Because of this androgenic activity, Primobolic is also contra-indicated in patients with prostatic carcinoma, since such substances may aggravate the disease.

DOSAGE AND DIRECTIONS FOR USE The therapy may have to be continued for at least 3 months at a dosage of 2-3 mg/kg bodyweight per day, ie 150mg for a person weighing 50 kg. Since some patients only respond after several months, treatment must not be stopped too soon. After improvement of the clinical picture treatment should, as a general rule, be continued for a further few weeks. Deterioration of the blood count after discontinuation of therapy may be reversed by renewed administration of Primobolic.

SIDE EFFECTS AND SPECIAL PRECAUTIONS In female patients, signs of virilisation (acne, hirsutism, hoarseness, possibly irreversible deepening of the voice) must be reckoned with; in sexually mature women menstrual irregularities may occur. In adult males, spermatogenesis may be inhibited, in boys there may be signs of premature puberty. Non-adult patients should be monitored for accelerated bone maturation by X-ray. Impairment of liver function is less frequent than with a 17alpha-alkylated medicines. In men, regular examinations of the prostate should be carried out prophylactically to exclude a malignant tumour.